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The future of sustainable human health and agriculture rests on our ability to view microbial evolution as part of the solution rather than the problem. Summer Fashion Oversized Sandals High Heel Women's shoesThe Koskella lab takes on this challenge by combining discovery-based science on plant microbiomes with hypothesis-driven experimentation. Our research examines host-microbe and microbe-microbe interactions by first identifying patterns in nature and then, in line with current theory where available,Tswsq Women Sandals Open Toe Slim High Heels Black Red Casual shoes Plus Size 4-20Genuine Leather Ankle Strap Heels Women Sandals Summer shoes Open Toe Chunky High Heels Ladies Sandals With Waterproof Platform Rivet Straw Sandals Thick High Heel Small Size Women's shoes Fashion Sexy Fashion shoesLeather Slipper, Women's colorful Backless Slippers Flowers Leather Vintage Boho Platform Flat Sandals,Red,5.5MUSgenerating predictions to explicitly test in the laboratory using a combination of experimental evolution, microbial ecology approaches, Lelehwhge Spring Summer Women Platform Wedge High Heels Fashion Lace-up Casual shoes White 5 M USand molecular biological techniques.
We focus primarily on how plant-microbiome, plant-pathogen, and bacteria-phage interactions occur, both as model systems for understanding fundamental principles and with the aim of leveraging these findings for design of novel disease management strategies. High Heels Women's shoes Sandals Cowhide Leather High Heel Platform Slope & Cross Lacing Women's shoes 12cm Ladies sandals (color Brown, Size 33)Women's Boots - Matte Suede in The Tube Snow Boots Winter Thick Warm Non-Slip Student shoes Cotton shoes 34-43We integrate ecological and evolutionary thinking with cutting-edge microbiological and molecular approaches to gain insight to microbiome establishment and function, within-microbiome interactions, and the role that microbiota and phages play in shaping disease. For more information on ongoing research projects, look here.
The Koskella lab at our end-of-semester lab lunch (May 2019)
A brief introduction to the lab and our recent research:
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I am an evolutionary ecologist interested in how species interactions influence genetic diversity within populations, diversity between populations, and species diversity at the community level. By combining evolutionary theory on coevolution, population dynamics, and infection genetics,Sexy PVC Jelly Sandals Crystal Transparent High Heels Slippers Slides Summer shoesJaHGDU orange pink Red Women's Casual Sandals Slippers Thick-Soled Indoor Linen Slip Home Slippers for WomenNene's Collection gold Women's Dance Fitness Ankle High Top Sneakers Nene's shoesNina Womens Tracey-yg Dress Pump I directly test the underlying assumptions and predicted outcomes of host-pathogen and microbial interactions through the lens of human health and agricultural sustainability.
My previous work was primarily focused on host – parasite coevolution; first between a smut fungus and a plant (e.g. Vallegreen Sneakers shoes Women in Silver Leather Casual Pearls Made in ), then a trematode and a snail (e.g. Shiney Women's High Heel Leather Booties Female Zipper Chunky Heel Plus Velvet Martin Boots), and most recently between bacteriophage viruses and the bacteria they infect, which are themselves parasites of plants (e.g. if phages are locally adapted to bacteria, Zoriana Spain Women's Boots Desert Suedeand Sneakers, Women's shoes, Autumn, Breathable, Casual, high Student Running shoes (color B, Size 35)). The types of fundamental questions I’ve address are:
1) How do pathogens/parasites adapt to better infect their hosts? And at what scale / speed are they capable of adapting?
Meaden, S., & Koskella, B. (2017). Adaptation of the pathogen, Pseudomonas syringae, AIWEIYi Womens Rivets Roman Gladiator Sandals Flats Thongs PinkWomen's Bernie Mev, Cindy Slip-On casual sport sandals BLACK SILVER 4 Mduring experimental evolution on a native vs. alternative host plant. Molecular ecology, 26(7), 1790-1801.
Koskella, B. (2014). Bacteria-phage interactions across time and space: merging local adaptation and time-shift experiments to understand phage evolution. The American Naturalist, 184(S1), S9-S21.
Koskella, B., Thompson, J. N., Preston, G. M., & Buckling, A. (2011). Summer Lady Buckle Back Rap Sandals Women High-Heeled Mixed colors Metal Button Sandals HeelsZandina Ladies Handmade 16cm High Heel Mary Janes Pumps LADYZDAF Sexy Fashion Evening Dress shoesLocal biotic environment shapes the spatial scale of bacteriophage adaptation to bacteria. The American Naturalist, 177(4), 440-451.
Greischar, M. A., & Koskella, B. (2007). A synthesis of experimental work on parasite local adaptation. Ecology Letters, 10(5), 418-434.
2) How do hosts respond to this adaptation (i.e. coevolve) and become more resistant to their local pathogens/parasites? Be fearless Fashion Solid Black Women shoes Woman Handmade Casual shoesINART...women Sandal shoes Open Toe Woman Pink Powder Pink Made in And are they paying a significant cost for this evolved resistance?Women's shoes, Thick Heel, Middle Heel, one Buckle, Single shoes, Women's Thick, Comfortable shoes (color B, Size 35)WANDA PANDA shoes Adele Tierra brown.
Koskella, B., & Parr, N. (2015). The evolution of bacterial resistance against bacteriophages in the horse chestnut phyllosphere is general across both space and time. Phil. Trans. R. Soc. B, 370(1675), 20140297.
Meaden, S., Paszkiewicz, K., & Koskella, B. (2015). The cost of phage resistance in a plant pathogenic bacterium is context‐dependent. Evolution, 69(5), 1321-1328.
Koskella, B. (2013). Phage-mediated selection on microbiota of a long-lived host. Current Biology, 23(13), 1256-1260.
Koskella, B., Lin, D. M., Buckling, A., & Thompson, J. N. (2011).Rocket Dog Womens Joanel 8a Canvas Cotton Rainbow Zip Fashion SneakerSoludos Womens Snake Platform Smoking Slipper Flat RHFDVGDS thick heels short boots pointy boots Martin sexy boots high heel Lady boots Spring ankle bootsNike Land Shark 3 4 Bg Black Tornado 5The costs of evolving resistance in heterogeneous parasite environments. Proceedings of the Royal Society of London B: Biological Sciences, rspb20112259.
3) Can antagonistic coevolution lead to increased diversity? For example, do pathogens/parasites preferentially target common hosts (i.e. the hosts that are the most fit) and therefore impose a rare-host advantage?
Morella, N. M., Gomez, A. L., Wang, G., Leung, M. S., & Koskella, B. (2018). The impact of bacteriophages on phyllosphere bacterial abundance and composition. Molecular ecology, 27(8), 2025-2038.
Koskella, B., & Lively, C. M. (2009). Evidence for negative frequency‐dependent selection during experimental coevolution of a freshwater snail and a sterilizing trematode. Evolution: International Journal of Organic Evolution, 63(9), 2213-2221.
and 4) Does this coevolution among hosts and parasites matter to human health, agriculture, and conservation? Can we use our understanding about when and how pathogens and commensals evolve to design better treatments and to predict and prevent the spread of diseases?
Koskella, B., & Taylor, T. B. (2018). Multifaceted impacts of bacteriophages in the plant microbiome. Annual review of phytopathology, 56, 361-380.
Lin, D., & Koskella, B. (2015). Friend and foe: High Heels Leather shoes Women Sandals High Heels with Buckle Toe Summer MulesDisposable slippers,spa slippers unisex Sauna Slippers Disposable Slippers Men's Slippers 25 Pairs Of Boys Thickening Anti-static color Non-slip Slippers EVA Women's Slippers Hotel Home Hospitality gufactors influencing the movement of the bacterium Helicobacter pylori along the parasitism–mutualism continuum. Evolutionary applications, 8(1), 9-22.
Meaden, S., & Koskella, B. (2013). Exploring the risks of phage application in the environment. Frontiers in microbiology, 4, 358.
So far, the body of evidence produced by the scientific community over decades of work suggests that parasites can evolve rapidly and specifically to infect their hosts, but that this doesn’t always mean they get more harmful or even better at infecting.Converse Alll Star Sneakers black shoes Unisex impermeabili Water ResistentBig Size Plus Slides Women Mules Summer Flatforms Slippers Ladies Straw Sandals Platform Wedge shoes There is also clear evidence that hosts respond by evolving increased resistance, and that this often comes at a cost such as decreased growth or reproduction. This ongoing coevolution, in which neither parasite nor host is winning the battle has been called ‘Red Queen’ dynamics, based on the idea from “Alice Through the Looking Glass” that you have to run as fast as you can just to stay in the same placeComfortable and beautiful ladies sandals Sandals Summer Female Flat Rubber Low-heeled Pink bluee shoesComfortable and beautiful ladies sandals Summer Flat Sandals Word with a New Simple Flat Women's shoes..GIY Women's Fashion Glitter Denim Ankle Boots Square Toe Studded Sequins Mid Heel Zip Dress Short BootiesSandals Summer Women Elegant Platform shoes Wedges Sandals Casual Non Slip Flats shoes Flat Sandals,Fashion Sandals (color A, Size 37) At last these ideas are beginning to be incorporated into the design and use of drug treatments (sometimes referred to as Darwinian Medicine) and used to build predictive models of disease spread in our increasingly-connected world. My work has taken advantage of a very powerful approach to address these questions by experimentally evolving hosts and parasites in the laboratory, Women's Sandals, Crystal Point Drill Open Toe Slip Breathable Lining Comfortable Women's High Heel Sandals,Black,42Odema Women's Leather Oxfords Wingtip Lace-up Low Heel Brogue Dress shoes Oxfordstherefore controlling for all the other “noise” out there in nature (Vallegreen Women's Slip On 36403).10 Pairs, Non-Slip Spa Guest Slippers Home Hospitality Floor colorful Soft Bread Slippers,004Carlo Valdini Fashion shoes Sling Back Block Heeled shoes Nude Honey However,AIWEIYi Womens Peep Toe Stiletto High Heels Pumps Ladies Slip-on Platform shoes for Party Dress BlackPropet Women's Sunburst Walker Slide I always try to go back to nature’s microcosm to find out whether what holds true in the lab can be used to explain what we see in the real world.RHFDVGDS Fish mouth high heels Fine sweet rhinestone high heel sandals with flowers Ladies platform high heels